Modeling the Double Peak Phenomenon in Drug Absorption Kinetics: The Case of Amisulpride

An interesting issue observed in some drugs is the “double peak phenomenon” (DPP). In DPP, concentration-time (C-t) profile does not follow usual shape but climbs to a and then begins degrade before rising again second peak. Such phenomenon case of amisulpride, which second-generation antipsychotic. The aim this study was develop model for description double peaks amisulpride after oral administration. Amisulpride plasma C-t data were obtained from 2 × crossover bioequivalence 24 healthy adult subjects. A nonlinear mixed-effects modeling approach applied order perform analysis. Participants’ characteristics, such as demographics (e.g., body weight, gender, etc.), have also been investigated. describing successfully developed. Simulations run using investigate impact significant covariates recommend appropriate dosage regimens. For comparison purposes suitability our developed phenomenon, previously published population pharmacokinetic models study.